Effect of intravenous lipid emulsion on bupivacaine plasma concentration in humans
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چکیده
منابع مشابه
Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity
Objective(s): The increasing use of methamphetamine (METH) in the last decades has made it the second most abused drug. Advancs in the area of intravenous lipid emulsion (ILE) have led to its potential application in the treatment of poisoning. The present study aims to investigate the potential role of ILE as an antidote for acute METH poisoning. Materials and Methods: Two groups of six male r...
متن کاملTolerance of mixed lipid emulsion in neonates: effect of concentration.
AIMS To compare the effect of concentration of a mixed lipid emulsion (50:50 medium chain triglyceride/long chain triglyceride) (MCT/LCT) on lipid tolerance in neonates. METHODS A prospective randomised controlled trial of 75 neonates requiring prolonged parenteral nutrition was conducted in the neonatal intensive care units of the Royal Maternity Hospital, Belfast, and the Waveney Hospital, ...
متن کاملThe effect of lipid emulsion on pharmacokinetics and tissue distribution of bupivacaine in rats.
BACKGROUND While lipid emulsion may reverse the systemic toxicity of bupivacaine, the pharmacokinetics and tissue distribution of bupivacaine after lipid emulsion infusion are not clear. In this study, we assessed the influence of lipid emulsion administration on the pharmacokinetics and tissue distribution of bupivacaine. METHODS Rats in the lipid group were administered IV bupivacaine at th...
متن کاملLipid emulsion reverses bupivacaine-induced asystole in isolated rat hearts: concentration-response and time-response relationships.
BACKGROUND The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined. METHODS Concentration response across a range of lipid concentrations (0-16%) to reverse bupivacaine-induced asystole were observed using isolated rat heart Langendorff preparation. Cardiac function parameters were recorded during infusion. ...
متن کاملIntravenous lipid emulsion in clinical toxicology
Intravenous lipid emulsion is an established, effective treatment for local anesthetic-induced cardiovascular collapse. The predominant theory for its mechanism of action is that by creating an expanded, intravascular lipid phase, equilibria are established that drive the offending drug from target tissues into the newly formed 'lipid sink'. Based on this hypothesis, lipid emulsion has been con...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 2012
ISSN: 0003-2409
DOI: 10.1111/j.1365-2044.2012.07056.x